HS Clinic is 東新宿クリニック‘s Web page in English.

At HS Clinic in Higashi-Shinjuku (東新宿) , Tokyo, we provide care for the local community in both general medicine and specialties including rheumatology, pain control and neurology.
We take care of English-speaking patients living in Japan as well.

Schedule an Appointment by Phone

If your’re a tourist in Tokyo and need an emergency service, please call or visit Hotlines listed below:

HIMAWARI by Metropolitan Tokyo Government
(Portal for Informaton on Clinics and Pharmacies in Tokyo)

HS Clinic – Our Team

Reiko Yamada, RN, will be your first contact with HS Clinic and will help you through the course of care.


Dr. Jaewon Park is a certified internist. He provides general medical care.


Dr. Shinichi Kawai is a certifed rheumatologist. He takes care of patients with rheumatoid arthritis and other connective tissue disorders. He serves as President of Japan Rheumatism Foundation.


Dr. Noriko Miyazawa is a certified pain clinician. She provides pain control services with nerve block and/or medication prescriptions.


Dr. Daisuke Ito is a certified neurologist. He takes care of patients with headache, migraine, memory loss or other neurological symptoms. He is Professor at Keio University Hospital Memory Clinic.

Dr. Hiroaki Kondo is Deputy Director of HS Clinic. He takes care of participants in clinical trials and oversees the whole process of trials conducted at HS Clinic.

We help patients with following symptoms:

  1. General medical problems including – but not limited to – fatigue, weight loss/gain, chest pain, abdominal pain, hypertension, anemia, diabetes, asthma, sleep apnea syndrome (SAS), and fever.
  • Rheumatoid arthritis, morning stiffness, arthralgias, and various rheumatologic disorders.
  • Chronic pains including headaches (migraines, tension type headache, cluster headache and others), trigeminal autonomic cephalgias (TACs), orofacial pains (trigeminal neuralgia, post-herpetic neuralgia and others), herniated spinal discs, spinal canal stenosis, lumbar spondylosis, osteoporosis, myofascial pain syndrome, neuropathic pains, cancer pain and others.
  • Neurological problems including memory loss, dementia (diagnosis, treatment, and prevention), tingling, dizziness, weakness, difficulty walking, loss of coordination, muscle cramps and twitches, difficulty swallowing/speaking/breathing, epilepsies, double vision, headaches, involuntary movement, tremor, and Parkinson’s disease.

A blood test to help assess the risk of dementia or MCI

  • A blood test to measure Amyloid beta1-42/1-40 ratio has been approved by the Japanese Ministry of Health Welfare and Labor for use in helping assess the risk of dementia or mild cognitive impairment (MCI). The test is not yet covered by the Japanses public health insurance. The test may be used to help rule in or rule out the diagnosis of dementia or MCI.
    The blood test for Amyloid beta1-42/1-40 ratio at HS Clinic is offered on Saturdays, when Dr. Daisuke Ito, a certified specialist of Japan Society for Dementia Research, is in the office.
    Pricing is as follows:
    Blood Test: Y70,000
    The test result will be presented with evaluation and advice from Dr. Ito.

Dementia Risk Reduction 2023

It has been known that treating hypertension, hearing problems, or depression can reduce the risk of suffering from dementia down the road. In the field of dementia research, year 2022 saw some significant progress, including the development of a blood test to assess the risk of future dementia. At HS Clinic, we provide a program including the following:
1. A blood test to assess the risk of dementia.
2. If deemed at high risk, medical management including treatment of risk factors – like hypertension – by Dr. Ito.

We provide home oxygen therapy for cluster headache

(Quoted from UK NHS) You should see a GP as soon as possible the first time you experience what you think may be a cluster headache. They’ll ask you about your symptoms and may refer you for tests. A brain scan is sometimes needed to exclude other conditions that can have similar symptoms to cluster headaches. Typically, with cluster headaches the brain scan is normal and the diagnosis is made on the basis of your symptoms without the need for further tests. If you’re diagnosed with cluster headaches, you’ll usually see a specialist, such as a neurologist (a specialist in brain and nerve conditions), to talk about your treatment options.
Cluster headaches are not life threatening, but they can cause severe pain and significantly affect your quality of life. Over-the-counter painkillers, such as paracetamol, are not effective for cluster headaches because they’re too slow to take effect. Instead, you’ll need to have one or more specialist treatments.
3 main treatments are available to relieve pain when taken soon after a cluster headache starts.
These are:
sumatriptan injections – which you can give yourself up to twice a day
sumatriptan or zolmitriptan nasal spray – which can be used if you do not want to have injections
oxygen therapy – where you breathe pure oxygen through a face mask
These treatments usually relieve the pain of a cluster headache within 15 to 30 minutes.


Pursed Lip Breathing

From time to time, patients with emphysema may have sudden shortness of breath, even at rest. Patients with asthma, another form of COPD, may experience the similar symptom, other than asthma attacks. This is caused by trapping of exhaled air (carbon dioxide) in the periphery of the lungs. Pursed Lip Breathing is the tried and tested way of relieving the shortness of breath in this situation. The video from American Lung Association explains how to do Pursed Lip Breathing and regain your breaths.

Immunization at HS Clinic

Following vaccines are available at HS Clinic. When you inquire about vaccines, please let us know your age and where you live – eg Shinjuku-ku.
Flu Vaccine
Shingles Vaccine (Varicella Zoster, VZV)
Human Papillomavirus Vaccine (HPV)


HS Clinic

3F Daito Bldg.
1-11-3 Okubo, Shinjuku-ku
Tokyo 1690072 Japan

Office Hours:
Mon, Tue, Wed, Fri:
9:30 ~ 12:30 and 14:00 ~ 18:00
Thursday: 14:00 ~ 17:00
Saturday: 9:00 ~ 12:00
Close on:
Thursday mornings, Saturday afternoons,
Sundays and national holidays.
Access Map

Keikokai Medical Corporation

Higashi-Shinjuku Clinic (HS Clinic) had been founded as an institution conducting bioequivalence studies. In December 2021, HS Clinic joined Keikokai Medical Corporation. Since then, the clinic has expanded its activities to phase 2 and phase 3 clinical trials for various disorders, such as obesity, diabetes mellitus, and pneumococcal infection. In April 2022, the clinic began offering clinical services to the general public.

Founded in 2007, Keikokai Medical Corporation has become one of the leading clinical trial institutions in Japan, conducting mostly phase 1 trials at P-one Clinic in Hachioji.

With incorporation of HS Clinic in 2021, Keikokai now operates two clinical trial sites in Hachioji and Shinjuku, both in Tokyo, covering all three phases of clinical trial.

Dr. Kenichi Furihata, Founder and Executive Director of P-one Clinic, serves also as Chairman of the Board of Trustees of Keikokai Medical Corporation.

MVN is P-one Clinics’s clinical trial volunteer network, for which more than 5,000 volunteers have registered, including non-Japanese participants.


Jaewon Park, MD, MPP

Specialty Certification:
Fellow of the Japanese Society of Internal Medicine
MD, Keio University School of Medicine, 1983
MPP, Georgetown University Graduate Public Policy Program, 1996
Professional Experience:
2022: Director, HS Clinic, Tokyo
2010: Part-time Lecturer, Tokai University School of Medicine
1996: Physician, Division of Hematology, Department of Medicine, National Tokyo Medical Center
1994: Fellow, Department of General Internal Medicine, Georgetown University, USA
1989: Physician, Department of Medicine, Second National Hospital, Tokyo
1987: Medical Resident, Department of Medicine, Keio University Hospital
1985: Physician, Department of Medicine, Tachikawa Hospital
1983: Medical Intern, Keio University Hospital

Shinichi Kawai, MD, PhD

Japan Rheumatism Foundation

Specialty Certification:
Emeritus Professor, Toho University
Certified Rheumatologist, Japan College of Rheumatology
Emeritus Member, Japanese Society of Clinical Pharmacology and Therapeutics
MD, Keio University School of Medicine, 1977
PhD, Keio University School of Medicine, 1985
Professional Experience:
2022: President, Japan Rheumatism Foundation
2022: Rheumatology Clinic, HS Clinic, Tokyo
2017: Professor (Endowed Chair), Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo
2012: Professor, Rheumatology Division, Department of Medicine, Toho University, Tokyo
2009: President, Japanese Society of Clinical Pharmacology and Therapeutics
2006: Congress Chair of the 27th Meeting of Japanese Society of Inflammation and Regeneration
2004: Professor, Division of Rheumatology, Toho University Omori Medical Center, Tokyo
1999: Professor, Institute of Medical Science, St. Marianna University School of Medicine, Tokyo
1995: Associate Professor, Institute of Medical Science, St. Marianna University School of Medicine, Tokyo
1991: Assistant Professor, Institute of Medical Science, St. Marianna University School of Medicine, Tokyo
1987: Medical Director, Division of Rheumatic Diseases, Tokyo Metropolitan Ohtsuka Hospital
1984: Guest Researcher, National Institutes of Health, USA
1977: Resident, Keio University Hospital, Tokyo
Japan College of Rheumatology Award
The Abbott Japan Award of Japan Rheumatism Foundation for Clinical Medicine of Rheumatic Diseases
Recent Selected References:
Current Therapeutic Drugs (Konnichi-no-chiryoyaku) 2022 (Eds. Shimada K, Kawai S, Izutsu K, Imai Y), Nankodo, Tokyo
1: Kawai S, Hasegawa J, Ito H, Fukuuchi Y, Nakano H, Ohtani H, Sasaki K, Adachi T. Efficacy and Safety of Twice-Daily Tramadol Hydrochloride Bilayer Sustained-Release Tablets with an Immediate Release Component for Postherpetic Neuralgia: Results of a Phase III, Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study. Pain Practice (in press)
2: Goto A, Sakamoto K, Kambayashi R, Izumi-Nakaseko H, Kawai S, Takei Y, Matsumoto A, Kanda Y, Sugiyama A. Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile. Toxicol Sci. 2022 Oct 27;190(1):99-109. doi: 10.1093/toxsci/kfac088. PMID: 35993620.
3: Kaneko K, Shikano K, Kawazoe M, Kawai S, Nanki T. Efficacy of Denosumab for Osteoporosis in Patients with Rheumatic Diseases. Intern Med. 2022;61(16):2405-2415. doi: 10.2169/internalmedicine.8560-21. Epub 2022 Aug 15. PMID: 35965073; PMCID: PMC9449617.
4: Kambayashi R, Goto A, Izumi-Nakaseko H, Takei Y, Matsumoto A, Kawai S, Sugiyama A. Roles of IK,ACh for perpetuating atrial fibrillation: Effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model. J Pharmacol Sci. 2022 Aug;149(4):175-178. doi: 10.1016/j.jphs.2022.05.004. Epub 2022 May 14. PMID: 35717070.
5: Takei Y, Amagase Y, Iida K, Sagawa T, Goto A, Kambayashi R, Izumi-Nakaseko H, Matsumoto A, Kawai S, Sugiyama A, Takada T, Hirasawa A. Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory. Geroscience. 2022 Aug;44(4):2305-2318. doi: 10.1007/s11357-022-00579-3. Epub 2022 May 20. PMID: 35593945; PMCID: PMC9616991.
6: Goto A, Kambayashi R, Izumi-Nakaseko H, Takei Y, Kawai S, Matsumoto A, Lurie KG, Sugiyama A. Magnitude of mitral valve closure plays a pivotal role in enhancing the forward blood flow during cardiac massage in dogs with ventricular fibrillation. J Vet Med Sci. 2022 Jun 18;84(6):877-880. doi: 10.1292/jvms.21-0583. Epub 2022 May 3. PMID: 35527014; PMCID: PMC9246689.
7: Kawai S, Sobajima S, Jinnouchi M, Nakano H, Ohtani H, Sakata M, Adachi T. Efficacy and Safety of Tramadol Hydrochloride Twice-Daily Sustained-Release Bilayer Tablets with an Immediate-Release Component for Chronic Pain Associated with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study. Clin Drug Investig. 2022 May;42(5):403-416. doi: 10.1007/s40261-022-01139-5. Epub 2022 Apr 18. PMID: 35435639; PMCID: PMC9106645.
8: Goto A, Kambayashi R, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Takei Y, Kawai S, Matsumoto A, Lurie KG, Sugiyama A. Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs. Heart Vessels. 2022 Oct;37(10):1808-1815. doi: 10.1007/s00380-022-02068-1. Epub 2022 Apr 15. PMID: 35426504.
9: Kambayashi R, Goto A, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Shinozaki M, Kawai S, Matsumoto A, Takei Y, Sugiyama A. Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane- anesthetized dogs: Reverse translational study. J Pharmacol Sci. 2022 Apr;148(4):343-350. doi: 10.1016/j.jphs.2022.01.011. Epub 2022 Jan 23. PMID: 35300808.
10: Kambayashi R, Goto A, Onozato M, Izumi-Nakaseko H, Takei Y, Matsumoto A, Kawai S, Fukushima T, Sugiyama A. Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model. J Pharmacol Sci. 2022 Jan;148(1):179-186. doi: 10.1016/j.jphs.2021.11.002. Epub 2021 Nov 13. PMID: 34924124

Noriko Miyazawa, MD, PhD

Board Certifications:
Pain Clinician
Anesthesiologist, Pediatric Anesthesiologist
Palliative Medicine
Occupational Health Physician
MD, Gifu University 1979
PhD, Keio University 1997
Professional Experience:
2022: Pain Control Clinic (Pain Management Clinic), HS Clinic, Tokyo
2010: Chief Anesthesiologist, Tokyo Metropolitan Children’s Medical Center
1988: Senior Anesthesiologist, Tokyo Metropolitan Ohtsuka Hospital
1986: Research Fellow, Anesthesiology and Pulmonary Medicine, Duke University (USA)
1981: Residency, Anesthesiology – Keio University, Tokyo
1979: Residency, Pediatrics – Keio University, Tokyo

Daisuke Ito, MD, PhD

Memory Clinic at Keio University Hospital
Research: Bench to Bedside (in Japanese)

Google ScholarDaisuke Ito’s Lab at Keio

Specialty Certification:
Board-certified Neurologist, Japanese Society of Neurology
Certified Specialist, Japan Society for Dementia Research
Certified Specialist, Japan Stroke Society
Certified Occupational Physician, Japan Medical Association
Fellow of the Japanese Society of Internal Medicine
MD, Keio University School of Medicine
PhD, Keio University School of Medicine, 1996
Professional Experience:
2022: Specially Designated Professor, Memory Clinic, Keio University School of Medicine, Tokyo
2019: Associate Professor, Department of Neurology, Keio University School of Medicine, Tokyo
2006: Senior Lecturer, Department of Neurology, Keio University School of Medicine, Tokyo
2005: Associate, Department of Neurology, Keio University School of Medicine, Tokyo
2001: Fellow, Department of Neurology, Pharmacology, and Physiology, The University of Chicago, USA
1996: Associate, Department of Neurology, Keio University School of Medicine, Tokyo
Young Investigator Award, Keio University School of Medicine Alumni Association
Japan Society for Dementia Research Award
Young Investigator Award, UBE Corporation, Japan
Selected References:
Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management.
Shimohama S, Tezuka T, Keisuke T, Bun S, Tabuchi H, Seki M, Momota Y, Suzuki N, Morimoto A, Iwabuchi Y, Kubota M, Yamamoto Y, Sano Y, Shikimoto R, Funaki K, Mimura Y, Nishimoto Y, Ueda R, Jinzaki M, Nakahara J, Mimura M, Ito D. Neurology. 2022 Sep 29:10.1212 [PMID: 36175151]
Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis.
Ito D, Morimoto S, Takahashi S, Okada K, Nakahara J, Okano H. Brain. 2022 Aug 25 [PMID: 36004509]
Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis.
Ito D. Ann Neurol. 2022 Jan;91(1):13-20. [doi: 10.1002/ana.26259]
RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.
Ito D, Hatano M, Suzuki N. Sci Transl Med. 2017 Nov 8;9(415) [PMID: 29118263]

Hiroaki Kondo, MD, PhD

1990: MD, Gifu University
1995: PhD, Gifu University Graduate School of Medicine (Bacteriology)
Professional Experience:
2022: Deputy Director, HS Clinic and P1 Clinic of Keikokai Medical Corporation
2020: Medical Director, HS Clinic of Keikokai Mediccal Corporation
2018: Medical Director, HS Clinic of Meiseikai Medical Corporation
2016: Medical Director, Global Medical Services, Parexel International, Tokyo
2011: Associate Medical Director, Medical Services, Parexel International, Tokyo
2009: Director, Hakusan-Dori Clinic of Rinseikai Medical Corporation, Tokyo
2008: Contracted General Internist, Kumagaya Seikyo Hospital, Saitama, Japan
2006: Therapeutic Area Physician for Vaccine, antimicrobials and gastroenterological products, Clinical R&D, Wyeth K.K., Tokyo
2001: Manager, Clinical safety, Medical Advisor and Clinical Trial Medicine Supervisor, Nippon Centocor K.K., Tokyo
1998: Manager, Gastroenterological Division, Nagahama City Hospital, Shiga, Japan
1997: Senior residency, Gastroenterology, Sapporo National Hospital, Hokkaido, Japan
1995: Residency, Internal medicine, Sapporo National Hospital, Hokkaido, Japan

By Metro, Rail or Bus

Higashi-Shinjuku Station
Metro Fukutoshin Line
: Shibuya, Shinjuku-sanchome, Ikebukuro, Wakoshi
Toei Oedo Line: Aoyama-itchome, Roppongi, Azabu-juban, Daimon, Kuramae, Ueno-okachimachi, Iidabashi, Shinjuku-nishiguchi, Nakano-sakaue

Seibu-Shinjuku Station
Seibu-Shinjuku Line
: Takadanobaba, Kodaira, Kokubunji, Higashi-Murayama, Tokorozawa

Shin-Okubo Station
JR Yamanote Line: Shinjuku, Ebisu, Meguro, Osaki, Shinagawa, Shimbashi, Tokyo, Ueno, Ikebukuro

Okubo Station
JR Chuo-Sobu Line: Chiba, Makuhari, Nishi-Funabashi, Ichikawa, Kinshicho, Akihabara, Iidabashi, Yotsuya, Nakano, Kichijoji, Mitaka, Tachikawa, Hachioji

Higashi-Shinjuku Bus Stop
Shinjuku Station, Takadanobaba Station, Shibuya Station, Omotesando, Yotsuya Station

We are an English-speaking medical team in Shinjuku, Tokyo.